NEW STEP BY STEP MAP FOR TRAMADOL (RETARD)

Opioid action is because of equally low affinity binding on the mum or dad compound and better affinity binding of your O-demethylated metabolite M1 to μ-opioid receptors. In animal versions, M1 is around six periods additional strong than tramadol in developing analgesia and two hundred periods more powerful in μ-opioid binding. Haven't been to